The Upjohn Company was a pharmaceutical manufacturing firm founded in 1886 in Hastings, Michigan, by Dr. William E. Upjohn, an 1875 graduate of the University of Michigan medical school.

The company was originally formed to make friable pills, which were specifically designed to be easily digested. These could be "reduced to a powder under the thumb", a strong marketing argument at the time.

1995, Upjohn merged with Pharmacia AB to form Pharmacia & Upjohn; the company was owned by Pfizer from 2015 until 2020.